3TJO

HtrA1 catalytic domain, mutationally inactivated

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, D)	Serine protease HTRA1	polymer	231	25131.7	3	UniProt (Q92743) Pfam (PF13365)	Homo sapiens (human)	High-temperature requirement A serine peptidase 1, L56, Serine protease 11
2	D, I (A, B)	octyl beta-D-glucopyranoside	non-polymer		292.4	2	Chemie (BOG)
3	E, F, G, J (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	H, K, L, M, N (A, B, D)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5	O, P, Q (A, B, D)	water	water		18.0	216	Chemie (HOH)

Sequence modifications

A, B, D: 161 - 370 (UniProt: Q92743)

PDB	External Database	Details
Met 140	-	expression tag
Gly 141	-	expression tag
Ser 142	-	expression tag
Ser 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
His 148	-	expression tag
His 149	-	expression tag
Ser 150	-	expression tag
Ser 151	-	expression tag
Gly 152	-	expression tag
Leu 153	-	expression tag
Val 154	-	expression tag
Pro 155	-	expression tag
Arg 156	-	expression tag
Gly 157	-	expression tag
Ser 158	-	expression tag
His 159	-	expression tag
Met 160	-	expression tag
Ala 328	Ser 328	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	75395.1
Non-Polymers*	Number of molecules	11
	Total formula weight	1429.5
All*	Total formula weight	76824.6

*Water molecules are not included.