3TJD
co-crystal structure of Jak2 with thienopyridine 19
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK2 | polymer | 298 | 35123.9 | 2 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 2, JAK-2 |
| 2 | C, D (A, B) | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide | non-polymer | 418.5 | 2 | Chemie (6TP) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A, B: 837 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Gly 835 | - | expression tag |
| Ser 836 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70247.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 837.1 | |
| All* | Total formula weight | 71084.8 |
