3TJC
Co-crystal structure of jak2 with thienopyridine 8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tyrosine-protein kinase JAK2 | polymer | 298 | 35123.9 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (human) | Janus kinase 2, JAK-2 |
| 2 | A, B | 4-amino-N-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide | non-polymer | 368.5 | 2 | Chemie (0TP) | |||
| 3 | water | water | 18.0 | 253 | Chemie (HOH) |
Sequence modifications
A, B: 837 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Gly 835 | - | EXPRESSION TAG |
| Ser 836 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70247.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 736.9 | |
| All* | Total formula weight | 70984.6 |
