3TIK
Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | sterol 14-alpha demethylase (CYP51) | polymer | 454 | 51302.6 | 4 | UniProt (Q385E8) Pfam (PF00067) | Trypanosoma brucei | |
| 2 | E, G, I, K (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, H, J, L (A, B, C, D) | 6-[(R)-(4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl]-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one | non-polymer | 505.9 | 4 | Chemie (JKF) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 32 - 481 (UniProt: Q385E8)
| PDB | External Database | Details |
|---|---|---|
| Lys 28 | - | expression tag |
| Gly 29 | - | expression tag |
| Lys 30 | - | expression tag |
| Leu 31 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 205210.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4489.7 | |
| All* | Total formula weight | 209700.0 |
