3TGE
A novel series of potent and selective PDE5 inhibitor1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 326 | 37610.2 | 1 | UniProt (O76074) Pfam (PF00233) | Homo sapiens (human) | cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | 7-(6-methoxypyridin-3-yl)-3-{[2-(morpholin-4-yl)ethyl]amino}-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one | non-polymer | 468.5 | 1 | Chemie (TGE) | |||
| 5 | E (A) | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A: 534 - 656 (UniProt: O76074)
A: 657 - 681 (PDB: 3TGE)
A: 682 - 858 (UniProt: O76074)
A: 657 - 681 (PDB: 3TGE)
A: 682 - 858 (UniProt: O76074)
| PDB | External Database | Details |
|---|---|---|
| Glu 751 | Gln 751 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37610.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 558.3 | |
| All* | Total formula weight | 38168.5 |
