3TG1

Crystal structure of p38alpha in complex with a MAPK docking partner

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 14	polymer	380	43509.5	1	UniProt (P47811) Pfam (PF00069) In PDB	Mus musculus (mouse)	MAP kinase 14, MAPK 14, CRK1, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha
2	B	Dual specificity protein phosphatase 10	polymer	158	18074.9	1	UniProt (Q9Y6W6) Pfam (PF00581) In PDB	Homo sapiens (human)	Mitogen-activated protein kinase phosphatase 5, MAP kinase phosphatase 5, MKP-5
3		water	water		18.0	15	Chemie (HOH)

Sequence modifications

A: 1 - 360 (UniProt: P47811)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

B: 139 - 288 (UniProt: Q9Y6W6)

PDB	External Database	Details
Met 138	-	expression tag
Glu 289	-	expression tag
His 290	-	expression tag
His 291	-	expression tag
His 292	-	expression tag
His 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61584.4
All*	Total formula weight	61584.4

*Water molecules are not included.