3TEI
Crystal structure of human ERK2 complexed with a MAPK docking peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 1 | polymer | 362 | 41444.6 | 1 | UniProt (P28482) Pfam (PF00069) | Homo sapiens (human) | MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2 |
| 2 | B (B) | Ribosomal protein S6 kinase alpha-1 | polymer | 24 | 2737.3 | 1 | UniProt (Q15418) | Homo sapiens | S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, p90-RSK 1, p90RSK1, p90S6K, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, Ribosomal S6 kinase 1, RSK-1 |
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) PubChem (4795) PubChem (33113) PubChem (445863) PubChem (6102784) PubChem (9543492) PubChem (14188278) PubChem (16058657) PubChem (23639785) PubChem (24794410) PubChem (44462678) PubChem (46926537) PubChem (54765332) PubChem (60063697) PubChem (66575078) PubChem (89688694) PubChem (92436779) PubChem (93005803) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: P28482)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 77 | Arg 77 | engineered mutation |
| Ala 314 | Glu 314 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44181.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 506.2 | |
| All* | Total formula weight | 44688.1 |
