3TAC

Crystal Structure of the Liprin-alpha/CASK complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Peripheral plasma membrane protein CASK	polymer	361	40732.8	1	UniProt (O14936) Pfam (PF00069) In PDB	Homo sapiens (human)	hCASK, Calcium/calmodulin-dependent serine protein kinase, Protein lin-2 homolog
2	B	Liprin-alpha-2	polymer	334	38466.8	1	UniProt (O75334) Pfam (PF00536) Pfam (PF07647) In PDB	Homo sapiens (human)	Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2, PTPRF-interacting protein alpha-2
3	A, B	SULFATE ION	non-polymer		96.1	7	Chemie (SO4)
4	B	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5		water	water		18.0	110	Chemie (HOH)

Sequence modifications

A: 1 - 345 (UniProt: O14936)

PDB	External Database	Details
Met -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Ser -8	-	expression tag
Ser -7	-	expression tag
Gly -6	-	expression tag
Leu -5	-	expression tag
Val -4	-	expression tag
Pro -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

B: 866 - 1193 (UniProt: O75334)

PDB	External Database	Details
Gly 860	-	expression tag
Pro 861	-	expression tag
Gly 862	-	expression tag
Ser 863	-	expression tag
Glu 864	-	expression tag
Phe 865	-	expression tag
Gln 993	Pro 993	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79199.6
Non-Polymers*	Number of molecules	8
	Total formula weight	707.9
All*	Total formula weight	79907.5

*Water molecules are not included.