3T9I

Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Proto-oncogene serine/threonine-protein kinase pim-1	polymer	328	37596.7	1	UniProt (P11309) Pfam (PF00069)	Homo sapiens (human)
2	B (A)	2-methoxy-4-(3-phenyl-2H-pyrazolo[3,4-b]pyridin-6-yl)phenol	non-polymer		317.3	1	Chemie (3T9)
3	C (A)	water	water		18.0	103	Chemie (HOH)

Sequence modifications

A: 2 - 313 (UniProt: P11309)

PDB	External Database	Details
Met -14	-	expression tag
Ala -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Leu -6	-	expression tag
Glu -5	-	expression tag
Val -4	-	expression tag
Leu -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Pro 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37596.7
Non-Polymers*	Number of molecules	1
	Total formula weight	317.3
All*	Total formula weight	37914.0

*Water molecules are not included.