3T64

5'-Diphenyl Nucleoside Inhibitors of Plasmodium falciparum dUTPase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	polymer	181	20632.2	3	UniProt (Q8II92) Pfam (PF00692) In PDB	Plasmodium falciparum 3D7
2	F	5'-(BENZHYDRYLAMINO)-2',5'-DIDEOXYURIDINE	polymer	3	298.3	1		Escherichia coli
3	A, B, C	2',5'-dideoxy-5'-[(diphenylmethyl)amino]uridine	non-polymer		393.4	3	Chemie (DU3)
4	A, B, C	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
5		water	water		18.0	322	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 173 (UniProt: Q8II92)

PDB	External Database	Details
Glu 174	-	expression tag
Ala 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag
His 179	-	expression tag
His 180	-	expression tag
His 181	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	62195.1
Non-Polymers*	Number of molecules	7
	Total formula weight	1564.6
All*	Total formula weight	63759.6

*Water molecules are not included.