3T64
5'-Diphenyl Nucleoside Inhibitors of Plasmodium falciparum dUTPase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | polymer | 181 | 20632.2 | 3 | UniProt (Q8II92) Pfam (PF00692) | Plasmodium falciparum 3D7 | |
| 2 | D (F) | 5'-(BENZHYDRYLAMINO)-2',5'-DIDEOXYURIDINE | polymer | 3 | 298.3 | 1 | Escherichia coli | ||
| 3 | E, G, I (A, B, C) | 2',5'-dideoxy-5'-[(diphenylmethyl)amino]uridine | non-polymer | 393.4 | 3 | Chemie (DU3) | |||
| 4 | F, H, J, K (A, B, C) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | L, M, N, O (A, B, C, F) | water | water | 18.0 | 322 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 173 (UniProt: Q8II92)
| PDB | External Database | Details |
|---|---|---|
| Glu 174 | - | expression tag |
| Ala 175 | - | expression tag |
| His 176 | - | expression tag |
| His 177 | - | expression tag |
| His 178 | - | expression tag |
| His 179 | - | expression tag |
| His 180 | - | expression tag |
| His 181 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62195.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1564.6 | |
| All* | Total formula weight | 63759.6 |
