3T1A
Crystal Structure of HIV-1 Reverse Transcriptase (K103N mutant) in Complex with Inhibitor M05
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Reverse Transcriptase | polymer | 563 | 64880.2 | 2 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | HIV-1 M:B_HXB2R (HIV-1) | Reverse transcriptase/ribonuclease H, Exoribonuclease H |
| 2 | C (A) | 1-(2,5-dichloro-3-{[5-chloro-1-(2H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-benzotriazol-4-yl]oxy}phenyl)methanamine | non-polymer | 474.7 | 1 | Chemie (5MA) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 268 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 560 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 103 | Lys 690 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 129760.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 474.7 | |
| All* | Total formula weight | 130235.2 |
