3T0E
Crystal structure of a complete ternary complex of T cell receptor, peptide-MHC and CD4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 182 | 21155.9 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B (B) | HLA class II histocompatibility antigen, DRB1-4 beta chain | polymer | 221 | 25169.8 | 1 | UniProt (P13760) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) | Homo sapiens (human) | MHC class II antigen DRB1*4, DR-4, DR4 |
| 3 | C (C) | T-cell receptor alpha chain | polymer | 206 | 22743.1 | 1 | Pfam (PF09291) UniProt (by SIFTS) (P01848) | Homo sapiens (human) | |
| 4 | D (D) | T-cell receptor beta chain | polymer | 245 | 27531.7 | 1 | Pfam (PF07654) UniProt (by SIFTS) (A0A5B9) | Homo sapiens (human) | |
| 5 | E (E) | T-cell surface glycoprotein CD4 | polymer | 373 | 41714.8 | 1 | UniProt (P01730) Pfam (PF05790) Pfam (PF00047) Pfam (PF09191) | Homo sapiens (human) | T-cell surface antigen T4/Leu-3 |
Sequence modifications
B: 30 - 221 (UniProt: P13760)
E: 1 - 363 (UniProt: P01730)
| PDB | External Database | Details |
|---|---|---|
| Phe 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Trp 3 | - | expression tag |
| Gly 4 | - | expression tag |
| Ala 5 | - | expression tag |
| Glu 6 | - | expression tag |
| Gly 7 | - | expression tag |
| Gln 8 | - | expression tag |
| Arg 9 | - | expression tag |
| Pro 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Phe 12 | - | expression tag |
| Gly 13 | - | expression tag |
| Ser 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Gly 16 | - | expression tag |
| Gly 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Leu 19 | - | expression tag |
| Val 20 | - | expression tag |
| Pro 21 | - | expression tag |
| Arg 22 | - | expression tag |
| Gly 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Gly 25 | - | expression tag |
| Gly 26 | - | expression tag |
| Gly 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Ser 29 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Tyr 40 | Gln 65 | engineered mutation |
| Trp 45 | Thr 70 | engineered mutation |
| Ala 364 | - | expression tag |
| Ala 365 | - | expression tag |
| Asp 366 | - | expression tag |
| Tyr 367 | - | expression tag |
| Lys 368 | - | expression tag |
| Asp 369 | - | expression tag |
| Asp 370 | - | expression tag |
| Asp 371 | - | expression tag |
| Asp 372 | - | expression tag |
| Lys 373 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 138315.2 | |
| All* | Total formula weight | 138315.2 |
