3T03
Crystal structure of PPAR gamma ligand binding domain in complex with a novel partial agonist GQ-16
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Peroxisome proliferator-activated receptor gamma | polymer | 284 | 32399.5 | 2 | UniProt (P37231) Pfam (PF00104) In PDB | Homo sapiens (human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
2 | C, D | Nuclear receptor coactivator 1 | polymer | 18 | 2119.4 | 2 | UniProt (Q15788) In PDB | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
3 | A, B | (5Z)-5-(5-bromo-2-methoxybenzylidene)-3-(4-methylbenzyl)-1,3-thiazolidine-2,4-dione | non-polymer | 418.3 | 2 | Chemie (3T0) | |||
4 | water | water | 18.0 | 316 | Chemie (HOH) |
Sequence modifications
A, B: 234 - 505 (UniProt: P37231)
PDB | External Database | Details |
---|---|---|
Met 222 | - | expression tag |
Gly 223 | - | expression tag |
Ser 224 | - | expression tag |
Ser 225 | - | expression tag |
His 226 | - | expression tag |
His 227 | - | expression tag |
His 228 | - | expression tag |
His 229 | - | expression tag |
His 230 | - | expression tag |
His 231 | - | expression tag |
Gly 232 | - | expression tag |
Gly 233 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 69037.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 836.6 | |
All* | Total formula weight | 69874.5 |