3SYT

Crystal structure of glutamine-dependent NAD+ synthetase from M. tuberculosis bound to AMP/PPi, NAD+, and glutamate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutamine-dependent NAD(+) synthetase	polymer	680	74855.4	4	UniProt (P0A5L6) Pfam (PF00795) Pfam (PF02540) UniProt (by SIFTS) (P9WJJ3)	Mycobacterium tuberculosis	NAD(+) synthase [glutamine-hydrolyzing]
2	E, J, N, S (A, B, C, D)	GLUTAMIC ACID	non-polymer		147.1	4	Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032)
3	F, K, P, T (A, B, C, D)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	4	Chemie (NAD)
4	G, L, Q, U (A, B, C, D)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	4	Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505)
5	H, M, R, V (A, B, C, D)	PYROPHOSPHATE 2-	non-polymer		176.0	4	Chemie (POP) PubChem (4995)
6	I, O (A, C)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL) PubChem (753)
7	W, X, Y, Z (A, B, C, D)	water	water		18.0	486	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 679 (UniProt: P0A5L6)

PDB	External Database	Details
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	299421.7
Non-Polymers*	Number of molecules	18
	Total formula weight	5519.1
All*	Total formula weight	304940.8

*Water molecules are not included.