3SX4
Crystal structure of human dpp-iv in complex with sa-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2-methyl-5h-pyrrolo[3,4-b]pyridin-7(6h)-one
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dipeptidyl peptidase 4 | polymer | 753 | 87450.8 | 2 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) In PDB | Homo sapiens (human) | ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form |
2 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
3 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 11 | Chemie (NAG) | |||
4 | A, B | 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)-2-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one | non-polymer | 428.3 | 2 | Chemie (KXA) | |||
5 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B: 39 - 766 (UniProt: P27487)
PDB | External Database | Details |
---|---|---|
Glu 37 | - | expression tag |
Phe 38 | - | expression tag |
Pro 767 | - | expression tag |
Leu 768 | - | expression tag |
Glu 769 | - | expression tag |
Gln 770 | - | expression tag |
Lys 771 | - | expression tag |
Leu 772 | - | expression tag |
Ile 773 | - | expression tag |
Ser 774 | - | expression tag |
Glu 775 | - | expression tag |
Glu 776 | - | expression tag |
Asp 777 | - | expression tag |
Leu 778 | - | expression tag |
Asn 779 | - | expression tag |
Ser 780 | - | expression tag |
Ala 781 | - | expression tag |
Val 782 | - | expression tag |
Asp 783 | - | expression tag |
His 784 | - | expression tag |
His 785 | - | expression tag |
His 786 | - | expression tag |
His 787 | - | expression tag |
His 788 | - | expression tag |
His 789 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 174901.7 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 3289.9 | |
All* | Total formula weight | 179040.4 |