3SWW
Crystal structure of human dpp-iv in complex with sa-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2-methyl-5h-pyrrolo[3,4-b]pyridin-7(6h)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dipeptidyl peptidase 4 | polymer | 753 | 87450.8 | 2 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (human) | ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form |
| 2 | C, D (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | E, F, G, H, I... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
| 4 | J, P (A, B) | 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one | non-polymer | 380.3 | 2 | Chemie (KXB) | |||
| 5 | Q, R (A, B) | water | water | 18.0 | 431 | Chemie (HOH) |
Sequence modifications
A, B: 39 - 766 (UniProt: P27487)
| PDB | External Database | Details |
|---|---|---|
| Glu 37 | - | expression tag |
| Phe 38 | - | expression tag |
| Pro 767 | - | expression tag |
| Leu 768 | - | expression tag |
| Glu 769 | - | expression tag |
| Gln 770 | - | expression tag |
| Lys 771 | - | expression tag |
| Leu 772 | - | expression tag |
| Ile 773 | - | expression tag |
| Ser 774 | - | expression tag |
| Glu 775 | - | expression tag |
| Glu 776 | - | expression tag |
| Asp 777 | - | expression tag |
| Leu 778 | - | expression tag |
| Asn 779 | - | expression tag |
| Ser 780 | - | expression tag |
| Ala 781 | - | expression tag |
| Val 782 | - | expression tag |
| Asp 783 | - | expression tag |
| His 784 | - | expression tag |
| His 785 | - | expression tag |
| His 786 | - | expression tag |
| His 787 | - | expression tag |
| His 788 | - | expression tag |
| His 789 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 174901.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2972.6 | |
| All* | Total formula weight | 178723.1 |
