3SRV
Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase SYK | polymer | 277 | 32162.0 | 1 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (human) | Spleen tyrosine kinase |
| 2 | B (B) | Tyrosine-protein kinase SYK | polymer | 277 | 32082.0 | 1 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (human) | Spleen tyrosine kinase |
| 3 | C, G (A, B) | 2-{[(3R,4R)-3-aminotetrahydro-2H-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide | non-polymer | 342.4 | 2 | Chemie (S19) | |||
| 4 | D, E, F, H (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 472 | Chemie (HOH) |
Sequence modifications
A: 360 - 635 (UniProt: P43405)
B: 360 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Gly 359 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 359 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64244.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1053.2 | |
| All* | Total formula weight | 65297.2 |
