3SRU
S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | X | Dihydrofolate reductase | polymer | 167 | 19347.1 | 1 | UniProt (P0A017) Pfam (PF00186) In PDB | Staphylococcus aureus | DHFR |
| 2 | X | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | X | N-[3'-(2,4-diaminoquinazolin-7-yl)-4'-ethoxybiphenyl-3-yl]methanesulfonamide | non-polymer | 449.5 | 1 | Chemie (Q26) | |||
| 4 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
X: 1 - 159 (UniProt: P0A017)
| PDB | External Database | Details |
|---|---|---|
| Leu 160 | - | expression tag |
| Glu 161 | - | expression tag |
| His 162 | - | expression tag |
| His 163 | - | expression tag |
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| His 166 | - | expression tag |
| His 167 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19347.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1192.9 | |
| All* | Total formula weight | 20540.0 |
