3SRD

Human M2 pyruvate kinase in complex with fructose 1-6 bisphosphate and Oxalate.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Pyruvate kinase isozymes M1/M2	polymer	551	60188.3	4	UniProt (P14618) Pfam (PF00224) Pfam (PF02887)	Homo sapiens (human)	Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58
2	E, J, O, T (A, B, C, D)	OXALATE ION	non-polymer		88.0	4	Chemie (OXL)
3	F, L, N, S (A, B, C, D)	1,6-di-O-phosphono-beta-D-fructofuranose	non-polymer		340.1	4	Chemie (FBP)
4	G, Q, V (A, C, D)	POTASSIUM ION	non-polymer		39.1	3	Chemie (K)
5	H, K, P, U (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
6	I, M, R, W, X (A, B, C, D)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
7	AA, BA, Y, Z (C, D, A, B)	water	water		18.0	126	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 531 (UniProt: P14618)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	240753.0
Non-Polymers*	Number of molecules	20
	Total formula weight	2387.5
All*	Total formula weight	243140.5

*Water molecules are not included.