3SRD
Human M2 pyruvate kinase in complex with fructose 1-6 bisphosphate and Oxalate.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase isozymes M1/M2 | polymer | 551 | 60188.3 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58 |
| 2 | E, J, O, T (A, B, C, D) | OXALATE ION | non-polymer | 88.0 | 4 | Chemie (OXL) PubChem (71081) | |||
| 3 | F, L, N, S (A, B, C, D) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) PubChem (16219368) PubChem (718) PubChem (24802138) PubChem (10267) PubChem (46937007) PubChem (172313) PubChem (440117) PubChem (89534552) PubChem (445557) PubChem (92209487) PubChem (92209485) PubChem (92209486) PubChem (124383956) PubChem (124540446) PubChem (5702629) PubChem (135053794) PubChem (123134048) PubChem (124202619) PubChem (124427861) PubChem (124524513) PubChem (124604817) PubChem (12800340) PubChem (130233858) PubChem (133126640) PubChem (135055131) PubChem (140434362) PubChem (146159004) PubChem (160510795) | |||
| 4 | G, Q, V (A, C, D) | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) PubChem (813) | |||
| 5 | H, K, P, U (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 6 | I, M, R, W, X (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) PubChem (753) | |||
| 7 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 240753.0 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2387.5 | |
| All* | Total formula weight | 243140.5 |
