3SR5

S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	X	Dihydrofolate reductase	polymer	166	19215.9	1	UniProt (P0A017) Pfam (PF00186) In PDB	Staphylococcus aureus	DHFR
2	X	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	1	Chemie (NAP)
3	X	7-(3,4-dimethoxyphenyl)-6-methylquinazoline-2,4-diamine	non-polymer		310.4	1	Chemie (Q12)
4		water	water		18.0	118	Chemie (HOH)

Sequence modifications

X: 2 - 159 (UniProt: P0A017)

PDB	External Database	Details
Leu 160	-	expression tag
Glu 161	-	expression tag
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19215.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1053.8
All*	Total formula weight	20269.6

*Water molecules are not included.