3SP6
Structural basis for iloprost as a dual PPARalpha/delta agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peroxisome proliferator-activated receptor alpha | polymer | 285 | 32342.6 | 1 | UniProt (Q07869) Pfam (PF00104) | Homo sapiens (human) | PPAR-alpha, Nuclear receptor subfamily 1 group C member 1 |
| 2 | B (B) | Peroxisome proliferator-activated receptor gamma coactivator 1-beta | polymer | 11 | 1213.5 | 1 | UniProt (Q86YN6) | Homo sapiens | PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PGC-1-related estrogen receptor alpha coactivator |
| 3 | C (A) | (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid | non-polymer | 360.5 | 1 | Chemie (IL2) | |||
| 4 | D (A) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 196 - 468 (UniProt: Q07869)
| PDB | External Database | Details |
|---|---|---|
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| Leu 190 | - | expression tag |
| Val 191 | - | expression tag |
| Pro 192 | - | expression tag |
| Arg 193 | - | expression tag |
| Gly 194 | - | expression tag |
| Ser 195 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33556.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 360.5 | |
| All* | Total formula weight | 33916.6 |
