3SNI
Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 345 | 39606.4 | 2 | UniProt (Q9Y233) In PDB | Homo sapiens (human) | |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | A, B | 2-methoxy-6,7-dimethyl-9-(4-methylpyridin-3-yl)imidazo[1,5-a]pyrido[3,2-e]pyrazine | non-polymer | 319.4 | 2 | Chemie (546) | |||
| 6 | water | water | 18.0 | 261 | Chemie (HOH) |
Sequence modifications
A, B: 439 - 779 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Gly 435 | - | expression tag |
| Ser 436 | - | expression tag |
| His 437 | - | expression tag |
| Met 438 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79212.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 889.1 | |
| All* | Total formula weight | 80101.9 |
