3SL6
Crystal structure of the catalytic domain of PDE4D2 with compound 12c
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 361 | 41523.9 | 4 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (human) | DPDE3, PDE43 |
| 2 | E, F, JA, KA, Q... (A, D, B, C) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | BA, CA, DA, EA, FA... (C, A, D, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 30 | Chemie (EDO) | |||
| 4 | HA, N, V, VA (C, A, B, D) | cyclopentyl 6-(ethylcarbamoyl)-2-[(thiophen-2-ylacetyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate | non-polymer | 461.6 | 4 | Chemie (JN8) | |||
| 5 | W (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | AA (C) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 7 | WA, XA, YA, ZA (A, B, C, D) | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 166095.5 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 4548.1 | |
| All* | Total formula weight | 170643.7 |
