3SKJ

Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (L, M)	Antibody, light chain	polymer	214	23482.1	2		Homo sapiens (human)
2	B, D (H, I)	Antibody, heavy chain	polymer	231	24420.3	2		Homo sapiens (human)
3	E, F (E, F)	Ephrin type-A receptor 2	polymer	206	23568.5	2	UniProt (P29317) Pfam (PF01404)	Homo sapiens (Human)	Epithelial cell kinase,Tyrosine-protein kinase receptor ECK
4	G, H, I, J, K (L, H, M, I, E)	water	water		18.0	43	Chemie (HOH)

Sequence modifications

E, F: -1 - 178 (UniProt: P29317)

PDB	External Database	Details
Ala -27	-	expression tag
Pro -26	-	expression tag
Glu -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
Asp -18	-	expression tag
Tyr -17	-	expression tag
Asp -16	-	expression tag
Ile -15	-	expression tag
Pro -14	-	expression tag
Thr -13	-	expression tag
Thr -12	-	expression tag
Glu -11	-	expression tag
Asn -10	-	expression tag
Leu -9	-	expression tag
Tyr -8	-	expression tag
Phe -7	-	expression tag
Gln -6	-	expression tag
Gly -5	-	expression tag
Ala -4	-	expression tag
Met -3	-	expression tag
Asp -2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	142941.7
All*	Total formula weight	142941.7

*Water molecules are not included.