3SJQ

Crystal structure of a small conductance potassium channel splice variant complexed with calcium-calmodulin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Calmodulin	polymer	149	16852.5	2	UniProt (P62161) Pfam (PF13499) UniProt (by SIFTS) (P0DP29)	Rattus norvegicus (rat)	CaM
2	C, D (C, D)	Small conductance calcium-activated potassium channel protein 2	polymer	87	10443.2	2	UniProt (P70604) Pfam (PF02888)	Rattus norvegicus (rat)	SK2, SKCa 2, SKCa2, KCa2.2
3	E, F, G, H, P... (A, B)	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)
4	DA, I, T, Z (D, A, B, C)	1-phenylurea	non-polymer		136.2	4	Chemie (PHU)
5	AA, J, K, L, M... (D, A, B)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
6	BA, CA, N, O, V... (D, A, B, C)	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
7	EA, FA, GA, HA (A, B, C, D)	water	water		18.0	340	Chemie (HOH)

Sequence modifications

C, D: 412 - 490 (UniProt: P70604)

PDB	External Database	Details
Ala 463	-	variant
Arg 464	-	variant
Lys 465	-	variant
Leu 491	-	expression tag
Glu 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	54591.6
Non-Polymers*	Number of molecules	26
	Total formula weight	2186.3
All*	Total formula weight	56777.9

*Water molecules are not included.