3SI5

Kinetochore-BUBR1 kinase complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	polymer	176	20578.6	2	UniProt (O60566) Pfam (PF08311)	Homo sapiens (human)	MAD3/BUB1-related protein kinase, hBUBR1, Mitotic checkpoint kinase MAD3L, Protein SSK1
2	C, D (X, Y)	Protein CASC5	polymer	24	2657.0	2	UniProt (Q8NG31)	Homo sapiens (human)	ALL1-fused gene from chromosome 15q14 protein, AF15q14, Bub-linking kinetochore protein, Blinkin, Cancer susceptibility candidate gene 5 protein, Cancer/testis antigen 29, CT29, Kinetochore-null protein 1, Protein D40/AF15q14
3	E, F, G, H (A, B, X, Y)	water	water		18.0	250	Chemie (HOH)

Sequence modifications

A, B: 57 - 220 (UniProt: O60566)

PDB	External Database	Details
Thr 45	-	expression tag
Gly 46	-	expression tag
Ser 47	-	expression tag
Thr 48	-	expression tag
Gly 49	-	expression tag
Ser 50	-	expression tag
Thr 51	-	expression tag
Gly 52	-	expression tag
Ser 53	-	expression tag
Thr 54	-	expression tag
Gly 55	-	expression tag
Ser 56	-	expression tag

X, Y: 208 - 226 (UniProt: Q8NG31)

PDB	External Database	Details
Gly 203	-	expression tag
Pro 204	-	expression tag
Leu 205	-	expression tag
Gly 206	-	expression tag
Ser 207	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	46471.3
All*	Total formula weight	46471.3

*Water molecules are not included.