3SH1
Ac-AChBP ligand binding domain mutated to human alpha-7 nAChR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Soluble acetylcholine receptor | polymer | 230 | 26323.1 | 10 | UniProt (Q8WSF8) | Aplysia californica (California sea hare) | |
| 2 | K, L, M, N (K, L, M, N) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | O, P (O, P) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | AA, GA, Q, SA, V (C, E, A, I, B) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) PubChem (888) | |||
| 5 | CA, FA, JA, MA, OA... (C, D, E, F, G...) | METHYLLYCACONITINE | non-polymer | 682.8 | 10 | Chemie (MLK) PubChem (16401493) PubChem (22209998) PubChem (23307250) PubChem (24207107) PubChem (16759265) PubChem (24848438) PubChem (25075992) PubChem (25200048) PubChem (21550736) PubChem (42617556) PubChem (22525004) PubChem (23350326) PubChem (25077276) PubChem (25200052) PubChem (494471) PubChem (42617558) PubChem (42617557) PubChem (44567311) PubChem (44575473) PubChem (54604862) PubChem (49874180) PubChem (5459119) PubChem (176519955) PubChem (177560881) PubChem (6426938) PubChem (107640) PubChem (6604691) PubChem (90661716) PubChem (90661963) PubChem (90661966) PubChem (441748) PubChem (72201037) PubChem (9961534) PubChem (11969792) PubChem (90479750) PubChem (90661977) PubChem (5288811) PubChem (5311278) PubChem (102601949) PubChem (118718698) PubChem (122173074) PubChem (124604697) PubChem (9874729) PubChem (126479971) PubChem (9939771) PubChem (127025916) PubChem (129010075) PubChem (129447850) PubChem (129490900) PubChem (10919507) PubChem (131664598) PubChem (134865857) PubChem (122361535) PubChem (11969093) PubChem (11972613) PubChem (137326926) PubChem (129447851) PubChem (129447852) PubChem (129447853) PubChem (139292146) PubChem (132427697) PubChem (134865859) PubChem (134865861) PubChem (134865862) PubChem (134866294) PubChem (134866465) PubChem (157630782) PubChem (163024200) PubChem (138404422) PubChem (165147107) PubChem (165339349) PubChem (139215932) PubChem (166177171) PubChem (168011766) PubChem (171318713) PubChem (171378657) PubChem (172430940) PubChem (172873984) PubChem (172938275) PubChem (163024196) PubChem (163024197) PubChem (163024198) PubChem (163024199) PubChem (163024201) PubChem (163024202) PubChem (163337811) PubChem (168008662) PubChem (168012028) PubChem (168315407) PubChem (170999944) PubChem (171039738) PubChem (171318715) PubChem (171350122) PubChem (172021418) PubChem (172038947) PubChem (172049488) PubChem (172432072) PubChem (173803415) | |||
| 6 | EA, HA, KA, S, Z (D, E, F, A, B) | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 5 | Chemie (MRD) PubChem (7870) PubChem (5288834) PubChem (5288845) | |||
| 7 | DA, PA, QA, T, U... (C, G, A, I, J) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 7 | Chemie (MPD) | |||
| 8 | BA, IA, LA, TA, UA... (C, E, F, I, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 9 | NA (G) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) PubChem (175) | |||
| 10 | AB, BB, CB, DB, EB... (B, C, D, E, F...) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J: 1 - 219 (UniProt: Q8WSF8)
| PDB | External Database | Details |
|---|---|---|
| Asp -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Tyr 32 | Thr 49 | engineered mutation |
| Ser 34 | Gly 51 | engineered mutation |
| Ser 36 | Thr 53 | engineered mutation |
| Leu 38 | Gln 55 | engineered mutation |
| Trp 55 | Tyr 72 | engineered mutation |
| Ser 59 | Arg 76 | engineered mutation |
| Asn 106 | Ile 123 | engineered mutation |
| Leu 108 | Val 125 | engineered mutation |
| Asn 110 | Thr 127 | engineered mutation |
| Ser 111 | His 128 | engineered mutation |
| Ser 112 | Asp 129 | engineered mutation |
| His 114 | Ser 131 | engineered mutation |
| Gln 116 | Met 133 | engineered mutation |
| Tyr 117 | Phe 134 | engineered mutation |
| Leu 118 | Ile 135 | engineered mutation |
| Ser 148 | Val 165 | engineered mutation |
| Gly 150 | Ser 167 | engineered mutation |
| Trp 152 | Phe 169 | engineered mutation |
| Ser 184 | Gln 201 | engineered mutation |
| Glu 185 | Val 202 | engineered mutation |
| Arg 186 | Gln 203 | engineered mutation |
| Phe 187 | His 204 | engineered mutation |
| Glu 189 | Ser 206 | engineered mutation |
| Lys 192 | Pro 209 | engineered mutation |
| Pro 196 | Ile 213 | engineered mutation |
| Ser 220 | - | expression tag |
| Arg 221 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 263230.5 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2870.7 | |
| Non-Polymers* | Number of molecules | 35 |
| Total formula weight | 9975.1 | |
| All* | Total formula weight | 276076.3 |
