3SGK
Unique carbohydrate/carbohydrate interactions are required for high affinity binding of FcgIII and antibodies lacking core fucose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fc fragment | polymer | 225 | 25336.7 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | C (C) | human Fcg3a receptor | polymer | 204 | 23384.3 | 1 | UniProt (P08637) Pfam (PF13895) | Homo sapiens (human) | |
| 3 | D, E (D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)][2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1520.4 | 2 | In PDB GlyTouCan (G59471TH) | |||
| 4 | F (F) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 5 | G (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | H (A) | MALONATE ION | non-polymer | 102.0 | 1 | Chemie (MLI) | |||
| 7 | I, J, K (A, B, C) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
C: 1 - 190 (UniProt: P08637)
| PDB | External Database | Details |
|---|---|---|
| Gln 38 | Asn 56 | engineered mutation |
| Gln 74 | Asn 92 | engineered mutation |
| Val 158 | Phe 176 | SEE REMARK 999 |
| Gln 169 | Asn 187 | engineered mutation |
| Gly 191 | - | expression tag |
| Lys 192 | - | expression tag |
| Lys 193 | - | expression tag |
| Lys 194 | - | expression tag |
| Lys 195 | - | expression tag |
| Lys 196 | - | expression tag |
| Lys 197 | - | expression tag |
| Gly 198 | - | expression tag |
| His 199 | - | expression tag |
| His 200 | - | expression tag |
| His 201 | - | expression tag |
| His 202 | - | expression tag |
| His 203 | - | expression tag |
| His 204 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 74057.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 4862.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 102.0 | |
| All* | Total formula weight | 79022.2 |
