3SFK
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 400 | 45270.8 | 1 | UniProt (Q08210) Pfam (PF01180) In PDB | Plasmodium falciparum 3D7 | Dihydroorotate oxidase, DHOdehase |
2 | A | 2-(1,1-difluoroethyl)-5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine | non-polymer | 357.3 | 1 | Chemie (D67) | |||
3 | A | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
4 | A | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
5 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 158 - 383 (UniProt: Q08210)
A: 414 - 569 (UniProt: Q08210)
PDB | External Database | Details |
---|---|---|
Met 140 | - | expression tag |
Gly 141 | - | expression tag |
His 142 | - | expression tag |
His 143 | - | expression tag |
His 144 | - | expression tag |
His 145 | - | expression tag |
His 146 | - | expression tag |
His 147 | - | expression tag |
Ala 148 | - | expression tag |
Glu 149 | - | expression tag |
Asn 150 | - | expression tag |
Leu 151 | - | expression tag |
Tyr 152 | - | expression tag |
Phe 153 | - | expression tag |
Gln 154 | - | expression tag |
Gly 155 | - | expression tag |
Ala 156 | - | expression tag |
Pro 157 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 45270.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 969.7 | |
All* | Total formula weight | 46240.5 |