3SFK

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dihydroorotate dehydrogenase (quinone), mitochondrial	polymer	400	45270.8	1	UniProt (Q08210) Pfam (PF01180)	Plasmodium falciparum 3D7	Dihydroorotate oxidase, DHOdehase
2	B (A)	2-(1,1-difluoroethyl)-5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine	non-polymer		357.3	1	Chemie (D67)
3	C (A)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	1	Chemie (FMN)
4	D (A)	OROTIC ACID	non-polymer		156.1	1	Chemie (ORO)
5	E (A)	water	water		18.0	5	Chemie (HOH)

Sequence modifications

A: 158 - 383 (UniProt: Q08210)

PDB	External Database	Details
Met 140	-	expression tag
Gly 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
Ala 148	-	expression tag
Glu 149	-	expression tag
Asn 150	-	expression tag
Leu 151	-	expression tag
Tyr 152	-	expression tag
Phe 153	-	expression tag
Gln 154	-	expression tag
Gly 155	-	expression tag
Ala 156	-	expression tag
Pro 157	-	expression tag

A: 414 - 569 (UniProt: Q08210)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	45270.8
Non-Polymers*	Number of molecules	3
	Total formula weight	969.7
All*	Total formula weight	46240.5

*Water molecules are not included.