3SCJ

Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus civet strain complexed with human receptor ACE2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Angiotensin-converting enzyme 2	polymer	603	69982.6	2	UniProt (Q9BYF1) Pfam (PF01401) In PDB	Homo sapiens (human)	ACE2, ACE-related carboxypeptidase, Angiotensin-converting enzyme homolog, ACEH, Metalloprotease MPROT15, Processed angiotensin-converting enzyme 2
2	E, F	Spike glycoprotein	polymer	186	21321.0	2	UniProt (P59594) Pfam (PF09408) In PDB	SARS coronavirus (SARS-CoV)	S glycoprotein, E2, Peplomer protein, Spike protein S1
3	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)

Sequence modifications

A, B: 19 - 615 (UniProt: Q9BYF1)

PDB	External Database	Details
His 616	-	expression tag
His 617	-	expression tag
His 618	-	expression tag
His 619	-	expression tag
His 620	-	expression tag
His 621	-	expression tag

E, F: 323 - 502 (UniProt: P59594)

PDB	External Database	Details
Pro 472	Leu 472	SEE REMARK 999
Arg 479	Asn 479	conflict
Gly 480	Asp 480	SEE REMARK 999
His 503	-	expression tag
His 504	-	expression tag
His 505	-	expression tag
His 506	-	expression tag
His 507	-	expression tag
His 508	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	182607.1
Non-Polymers*	Number of molecules	4
	Total formula weight	201.7
All*	Total formula weight	182808.8

*Water molecules are not included.