3S9N
Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, room temperature
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transferrin receptor protein 1 | polymer | 654 | 73533.2 | 2 | UniProt (P02786) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) | Homo sapiens (human) | TR, TfR, TfR1, Trfr, T9, p90, Transferrin receptor protein 1, serum form, sTfR |
| 2 | C, D (C, D) | Serotransferrin | polymer | 693 | 76980.4 | 2 | UniProt (P02787) Pfam (PF00405) | Homo sapiens (human) | Transferrin, Beta-1 metal-binding globulin, Siderophilin |
| 3 | E, G (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 4 | F, H (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | I, K (C, D) | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) | |||
| 6 | J, L (C, D) | CARBONATE ION | non-polymer | 60.0 | 2 | Chemie (CO3) |
Sequence modifications
A, B: 120 - 760 (UniProt: P02786)
C, D: 1 - 679 (UniProt: P02787)
| PDB | External Database | Details |
|---|---|---|
| Val 107 | - | expression tag |
| Pro 108 | - | expression tag |
| Asp 109 | - | expression tag |
| Lys 110 | - | expression tag |
| His 111 | - | expression tag |
| His 112 | - | expression tag |
| His 113 | - | expression tag |
| His 114 | - | expression tag |
| His 115 | - | expression tag |
| His 116 | - | expression tag |
| Ile 117 | - | expression tag |
| Glu 118 | - | expression tag |
| Gly 119 | - | expression tag |
| Ser 142 | Gly 142 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Val -13 | - | expression tag |
| Pro -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Lys -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Ile -3 | - | expression tag |
| Glu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Asp 413 | Asn 432 | engineered mutation |
| Phe 426 | Tyr 445 | engineered mutation |
| Val 429 | Ile 448 | SEE REMARK 999 |
| Phe 517 | Tyr 536 | engineered mutation |
| Asp 611 | Asn 630 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 301027.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 754.3 | |
| All* | Total formula weight | 301781.3 |
