3S8V

Crystal structure of LRP6-Dkk1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Low-density lipoprotein receptor-related protein 6	polymer	623	70828.7	2	UniProt (O75581) Pfam (PF00058) Pfam (PF14670)	Homo sapiens (human)	LRP-6
2	C (X)	Dickkopf-related protein 1	polymer	88	9776.2	1	UniProt (O94907) Pfam (PF21481) Pfam (PF21479)	Homo sapiens (human)	Dickkopf-1, Dkk-1, hDkk-1, SK

Sequence modifications

A, B: 629 - 1243 (UniProt: O75581)

PDB	External Database	Details
His 621	-	expression tag
His 622	-	expression tag
His 623	-	expression tag
His 624	-	expression tag
His 625	-	expression tag
His 626	-	expression tag
His 627	-	expression tag
His 628	-	expression tag
Ile 1062	Val 1062	conflict

X: 183 - 266 (UniProt: O94907)

PDB	External Database	Details
Gly 179	-	expression tag
Pro 180	-	expression tag
Gly 181	-	expression tag
Ser 182	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	151433.7
All*	Total formula weight	151433.7

*Water molecules are not included.