3S4S

Crystal structure of CD4 mutant bound to HLA-DR1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	HLA class II histocompatibility antigen, DR alpha chain	polymer	182	21145.9	2	UniProt (P01903) Pfam (PF00993) Pfam (PF07654) In PDB	Homo sapiens (human)	MHC class II antigen DRA
2	B, E	HLA class II histocompatibility antigen, DRB1-1 beta chain	polymer	193	22456.1	2	UniProt (P04229) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) In PDB	Homo sapiens (human)	MHC class II antigen DRB1*1, DR-1, DR1
3	C, F	Hemagglutinin peptide	polymer	13	1506.8	2	UniProt (Q9YS52) UniProt (by SIFTS) (P03437) In PDB	Influenza A virus
4	G, H	T-cell surface glycoprotein CD4	polymer	191	21260.1	2	UniProt (P01730) Pfam (PF00047) Pfam (PF05790) In PDB	Homo sapiens (human)	T-cell surface antigen T4/Leu-3
5	B, D, E	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6		water	water		18.0	68	Chemie (HOH)

Sequence modifications

A, D: 1 - 182 (UniProt: P01903)

PDB	External Database	Details
Gln 177	His 202	CONFLICT

B, E: 1 - 192 (UniProt: P04229)

PDB	External Database	Details
Met 0	-	EXPRESSION TAG

G, H: 1 - 178 (UniProt: P01730)

PDB	External Database	Details
Asp -3	-	EXPRESSION TAG
Leu -2	-	EXPRESSION TAG
Gly -1	-	EXPRESSION TAG
Ser 0	-	EXPRESSION TAG
Tyr 40	Gln 65	CONFLICT
Trp 45	Thr 70	CONFLICT
Ala 179	-	EXPRESSION TAG
Ala 180	-	EXPRESSION TAG
Ala 181	-	EXPRESSION TAG
His 182	-	EXPRESSION TAG
His 183	-	EXPRESSION TAG
His 184	-	EXPRESSION TAG
His 185	-	EXPRESSION TAG
His 186	-	EXPRESSION TAG
His 187	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	132737.8
Non-Polymers*	Number of molecules	3
	Total formula weight	276.3
All*	Total formula weight	133014.1

*Water molecules are not included.