3S4J
Human FDPS Synthase in Complex with a Rigid Analog of Risedronate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Farnesyl pyrophosphate synthase | polymer | 349 | 40116.8 | 1 | UniProt (P14324) Pfam (PF00348) | Homo sapiens (human) | FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase |
| 2 | B (A) | 6,7-dihydro-5H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid) | non-polymer | 279.1 | 1 | Chemie (UNV) | |||
| 3 | C, D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | F (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | G (A) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 5 - 353 (UniProt: P14324)
| PDB | External Database | Details |
|---|---|---|
| Ser 5 | Gln 71 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40116.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 448.1 | |
| All* | Total formula weight | 40564.9 |
