3S3J
Transglutaminase 2 in complex with a novel inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein-glutamine gamma-glutamyltransferase 2 | polymer | 694 | 78312.6 | 1 | UniProt (P21980) Pfam (PF00868) Pfam (PF01841) Pfam (PF00927) | Homo sapiens (human) | Tissue transglutaminase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2 |
| 2 | B (B) | Peptide inhibitor | polymer | 5 | 634.1 | 1 | BIRD (PRD_000935) | synthetic construct | |
| 3 | C, D, E, F, G... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | I (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A: 2 - 687 (UniProt: P21980)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| Ala -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78946.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 668.5 | |
| All* | Total formula weight | 79615.3 |
