3S35
Structural basis for the function of two anti-VEGF receptor antibodies
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | 6.64 Fab heavy chain | polymer | 217 | 23645.6 | 1 | Mus musculus Homo sapiens (mouse human) | ||
| 2 | B (L) | 6.64 Fab light chain | polymer | 217 | 23899.3 | 1 | Mus musculus Homo sapiens (mouse human) | ||
| 3 | C (X) | Vascular endothelial growth factor receptor 2 | polymer | 122 | 13504.3 | 1 | UniProt (P35968) Pfam (PF00047) | Homo sapiens (human) | VEGFR-2, Fetal liver kinase 1, FLK-1, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1 |
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E, F, G, H, J... (H, L, X) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 6 | I (X) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | L, M, N (H, L, X) | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
X: 220 - 338 (UniProt: P35968)
| PDB | External Database | Details |
|---|---|---|
| Ala 217 | - | expression tag |
| Asp 218 | - | expression tag |
| Pro 219 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 61049.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 461.7 | |
| All* | Total formula weight | 61935.3 |
