3RZC

Structure of the self-antigen iGb3 bound to mouse CD1d and in complex with the iNKT TCR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Antigen-presenting glycoprotein CD1d1	polymer	285	32632.7	1	UniProt (P11609) Pfam (PF16497) Pfam (PF07654)	Mus musculus (mouse)
2	B (B)	Beta-2-microglobulin	polymer	99	11660.4	1	UniProt (P01887) Pfam (PF07654)	Mus musculus (mouse)
3	C (C)	Valpha14	polymer	209	23055.6	1		Mus musculus Homo sapiens
4	D (D)	Vbeta8.2	polymer	241	27027.0	1		Mus musculus Homo sapiens
5	E, F (E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	G (G)	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G70885YM)
7	H (A)	N-[(2S,3R,4E)-1-{[alpha-D-galactopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]hexacosanamide	non-polymer		1164.6	1	Chemie (LGN)
8	I, J, K, L (A, B, C, D)	water	water		18.0	48	Chemie (HOH)

Sequence modifications

A: 1 - 279 (UniProt: P11609)

PDB	External Database	Details
His 201	Asp 219	conflict
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag

B: 1 - 99 (UniProt: P01887)

PDB	External Database	Details
Ala 85	Asp 105	variant

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	94375.6
Branched	Number of molecules	3
	Total formula weight	1581.5
Non-Polymers*	Number of molecules	1
	Total formula weight	1164.6
All*	Total formula weight	97121.7

*Water molecules are not included.