3RQD
Ideal Thiolate-Zinc Coordination Geometry in Depsipeptide Binding to Histone Deacetylase 8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone deacetylase 8 | polymer | 389 | 43232.0 | 2 | UniProt (Q9BY41) Pfam (PF00850) | Homo sapiens (human) | HD8 |
| 2 | C, D (C, D) | Largazole | polymer | 5 | 550.7 | 2 | BIRD (PRD_000785) | Symploca | |
| 3 | E, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, G, I, J (A, B) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 504 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 377 (UniProt: Q9BY41)
| PDB | External Database | Details |
|---|---|---|
| Ile 378 | - | expression tag |
| Glu 379 | - | expression tag |
| Gly 380 | - | expression tag |
| Arg 381 | - | expression tag |
| Gly 382 | - | expression tag |
| Ser 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
| His 388 | - | expression tag |
| His 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 87565.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 287.2 | |
| All* | Total formula weight | 87852.6 |
