3ROC
Crystal structure of human p38 alpha complexed with a pyrimidinone compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 360 | 41343.2 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (human) | MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, SAPK2A |
| 2 | B (A) | 3-{5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl}-N-(2-hydroxyethyl)-4-methylbenzamide | non-polymer | 449.8 | 1 | Chemie (29A) | |||
| 3 | C (A) | 4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine | non-polymer | 239.2 | 1 | Chemie (29B) | |||
| 4 | D (A) | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41343.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 689.1 | |
| All* | Total formula weight | 42032.3 |
