3RNY

Crystal structure of human RSK1 C-terminal kinase domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ribosomal protein S6 kinase alpha-1	polymer	346	38822.4	2	UniProt (Q15418) Pfam (PF00069)	Homo sapiens (human)	S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, p90-RSK 1, p90RSK1, p90S6K, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, Ribosomal S6 kinase 1, RSK-1
2	C, D (A, B)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
3	E, F (A, B)	water	water		18.0	43	Chemie (HOH)

Sequence modifications

A, B: 411 - 735 (UniProt: Q15418)

PDB	External Database	Details
Met 390	-	expression tag
Gly 391	-	expression tag
Ser 392	-	expression tag
Ser 393	-	expression tag
His 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag
His 397	-	expression tag
His 398	-	expression tag
His 399	-	expression tag
Ser 400	-	expression tag
Ser 401	-	expression tag
Gly 402	-	expression tag
Leu 403	-	expression tag
Val 404	-	expression tag
Pro 405	-	expression tag
Arg 406	-	expression tag
Gly 407	-	expression tag
Ser 408	-	expression tag
His 409	-	expression tag
Met 410	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77644.7
Non-Polymers*	Number of molecules	2
	Total formula weight	46.0
All*	Total formula weight	77690.7

*Water molecules are not included.