3RLP
Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-6-methylpyrimidin-2-amine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Heat shock protein HSP 90-alpha | polymer | 226 | 25582.8 | 2 | UniProt (P07900) Pfam (PF13589) In PDB | Homo sapiens (human) | Heat shock 86 kDa, HSP 86, HSP86, Renal carcinoma antigen NY-REN-38 |
2 | A, B | 4-(2,4-dichloro-5-methoxyphenyl)-6-methylpyrimidin-2-amine | non-polymer | 284.1 | 2 | Chemie (3RP) | |||
3 | B | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
4 | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 225 (UniProt: P07900)
PDB | External Database | Details |
---|---|---|
Met 8 | - | expression tag |
Leu 226 | - | expression tag |
Glu 227 | - | expression tag |
His 228 | - | expression tag |
His 229 | - | expression tag |
His 230 | - | expression tag |
His 231 | - | expression tag |
His 232 | - | expression tag |
His 233 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 51165.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 663.3 | |
All* | Total formula weight | 51829.0 |