3RKI

Structural basis for immunization with post-fusion RSV F to elicit high neutralizing antibody titers

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Fusion glycoprotein F0	polymer	528	58487.6	3	UniProt (P03420)	Human respiratory syncytial virus	Protein F, Fusion glycoprotein F2, Fusion glycoprotein F1
2	D, E, F, G, H... (D, E, F, G, H...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
3	J (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A, B, C: 1 - 524 (UniProt: P03420)

PDB	External Database	Details
Ala 111	Pro 102	variant
-	Phe 137	deletion
-	Leu 138	deletion
-	Gly 139	deletion
-	Phe 140	deletion
-	Leu 141	deletion
-	Leu 142	deletion
-	Gly 143	deletion
-	Val 144	deletion
-	Gly 145	deletion
Val 379	Ile 379	variant
Val 447	Met 447	variant
Gly 525	-	expression tag
Gly 526	-	expression tag
Ser 527	-	expression tag
Ala 528	-	expression tag
Gly 529	-	expression tag
Ser 530	-	expression tag
Gly 531	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	175462.9
Branched	Number of molecules	6
	Total formula weight	2546.4
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	178230.5

*Water molecules are not included.