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3RJW

Crystal structure of histone lysine methyltransferase g9a with an inhibitor

Replaces:  3NNI
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BHistone-lysine N-methyltransferase EHMT2polymer28332604.92UniProt (Q96KQ7)
Pfam (PF05033)
Pfam (PF00856)
In PDB
Homo sapiens (human)Euchromatic histone-lysine N-methyltransferase 2, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, Lysine N-methyltransferase 1C, Protein G9a
2B, AZINC IONnon-polymer65.48Chemie (ZN)
3B, AS-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.42Chemie (SAH)
4B, A2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)piperidin-4-yl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-aminenon-polymer509.72Chemie (CIQ)
5B, AUNKNOWN ATOM OR IONnon-polymer29Chemie (UNX)
6waterwater18.047Chemie (HOH)
Sequence modifications
A, B: 913 - 1193 (UniProt: Q96KQ7)
PDBExternal DatabaseDetails
Gly 911-expression tag
Ser 912-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight65209.8
Non-Polymers*Number of molecules41
Total formula weight2311.5
All*Total formula weight67521.4
*Water molecules are not included.

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PDB entries from 2024-07-10

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