3RIF
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and glutamate.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Avermectin-sensitive glutamate-gated chloride channel GluCl alpha | polymer | 347 | 39636.6 | 5 | UniProt (O17793) | Caenorhabditis elegans (nematode) | |
| 2 | F, G, H, I, J (F, G, H, I, J) | Mouse monoclonal Fab fragment, heavy chain | polymer | 221 | 23921.7 | 5 | Mus musculus (mouse) | ||
| 3 | K, L, M, N, O (K, L, M, N, O) | Mouse monoclonal Fab fragment, light chain | polymer | 210 | 22618.2 | 5 | Mus musculus (mouse) | ||
| 4 | BA, DA, GA, P, U (C, D, E, A, B) | GLUTAMIC ACID | non-polymer | 147.1 | 5 | Chemie (GLU) | |||
| 5 | EA, HA, Q, R, W (D, E, A, B) | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside | non-polymer | 875.1 | 5 | Chemie (IVM) | |||
| 6 | S, T, X (A, B) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 3 | Chemie (LMT) | |||
| 7 | V (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | CA, JA, Y (C, E, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 9 | FA, IA, Z (D, E, B) | N-OCTANE | non-polymer | 114.2 | 3 | Chemie (OCT) | |||
| 10 | AA (B) | UNDECANE | non-polymer | 156.3 | 1 | Chemie (UND) |
Sequence modifications
A, B, C, D, E: 1 - 302 (UniProt: O17793)
A, B, C, D, E: 312 - 338 (UniProt: O17793)
| PDB | External Database | Details |
|---|---|---|
| His 340 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
| His 347 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 303 | - | linker |
| Gly 304 | - | linker |
| Thr 305 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 430882.6 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 7841.0 | |
| All* | Total formula weight | 438723.7 |
