3RIB

Human lysine methyltransferase Smyd2 in complex with AdoHcy

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	N-lysine methyltransferase SMYD2	polymer	441	50831.2	2	UniProt (Q9NRG4) Pfam (PF00856) Pfam (PF01753)	Homo sapiens (human)	HSKM-B, Histone methyltransferase SMYD2, Lysine N-methyltransferase 3C, SET and MYND domain-containing protein 2
2	C, D, E, N, O... (A, B)	ZINC ION	non-polymer		65.4	6	Chemie (ZN)
3	F, Q (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
4	G, H, I, J, K... (A, B)	SULFATE ION	non-polymer		96.1	9	Chemie (SO4)
5	T, U (A, B)	water	water		18.0	49	Chemie (HOH)

Sequence modifications

A, B: 1 - 433 (UniProt: Q9NRG4)

PDB	External Database	Details
Leu 434	-	expression tag
Glu 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
His 441	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	101662.5
Non-Polymers*	Number of molecules	17
	Total formula weight	2025.8
All*	Total formula weight	103688.3

*Water molecules are not included.