3RHX
Crystal structure of the catalytic domain of FGFR1 kinase in complex with ARQ 069
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Basic fibroblast growth factor receptor 1 | polymer | 306 | 34908.1 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (human) | FGFR-1, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, Proto-oncogene c-Fgr |
| 2 | C, F (B, A) | (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine | non-polymer | 273.3 | 2 | Chemie (3RH) | |||
| 3 | D (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | E, G, H, I, J (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | K, L (B, A) | water | water | 18.0 | 488 | Chemie (HOH) |
Sequence modifications
B, A: 461 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 460 | - | expression tag |
| Ala 488 | Cys 488 | engineered mutation |
| Ser 584 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69816.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 953.1 | |
| All* | Total formula weight | 70769.2 |
