3RHW
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Avermectin-sensitive glutamate-gated chloride channel GluCl alpha | polymer | 347 | 39636.6 | 5 | UniProt (O17793) | Caenorhabditis elegans (nematode) | |
| 2 | F, G, H, I, J (F, G, H, I, J) | Mouse monoclonal Fab fragment, heavy chain | polymer | 221 | 23921.7 | 5 | Mus musculus (mouse) | ||
| 3 | K, L, M, N, O (K, L, M, N, O) | Mouse monoclonal Fab fragment, light chain | polymer | 210 | 22618.2 | 5 | Mus musculus (mouse) | ||
| 4 | AA, BA, P, T, U (D, A, B) | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside | non-polymer | 875.1 | 5 | Chemie (IVM) PubChem (23307238) PubChem (23307262) PubChem (177678855) PubChem (16760011) PubChem (44393100) PubChem (21584398) PubChem (23307215) PubChem (42648499) PubChem (44306127) PubChem (45114068) PubChem (66509061) PubChem (71308642) PubChem (53384911) PubChem (73438913) PubChem (56603652) PubChem (57182275) PubChem (73952278) PubChem (58594796) PubChem (59707377) PubChem (66577025) PubChem (70678372) PubChem (177065624) PubChem (177678952) PubChem (51025) PubChem (156069) PubChem (71749648) PubChem (73265241) PubChem (73357349) PubChem (73952283) PubChem (73952837) PubChem (74764330) PubChem (91407038) PubChem (3085416) PubChem (90479776) PubChem (90908120) PubChem (4330618) PubChem (118476986) PubChem (6419971) PubChem (6427057) PubChem (6440492) PubChem (6450358) PubChem (122172888) PubChem (6603890) PubChem (123132485) PubChem (6857963) PubChem (6914288) PubChem (6713922) PubChem (123456077) PubChem (6071412) PubChem (124870644) PubChem (124870718) PubChem (124929025) PubChem (124929026) PubChem (124929023) PubChem (125528694) PubChem (125528697) PubChem (125528696) PubChem (126963352) PubChem (6321424) PubChem (129010219) PubChem (129606809) PubChem (6604429) PubChem (6912779) PubChem (133562698) PubChem (112547093) PubChem (118477994) PubChem (11957587) PubChem (138106966) PubChem (139031854) PubChem (139594279) PubChem (145997404) PubChem (124870719) PubChem (124870720) PubChem (146159550) PubChem (124917050) PubChem (124917051) PubChem (124917052) PubChem (124918216) PubChem (124929024) PubChem (155970341) PubChem (155982218) PubChem (156599123) PubChem (162935621) PubChem (162935625) PubChem (162935623) PubChem (162935627) PubChem (125528695) PubChem (164724784) PubChem (168268469) PubChem (168312921) PubChem (171136628) PubChem (171689455) PubChem (172012500) PubChem (172878361) PubChem (172898004) PubChem (173492688) PubChem (173479738) PubChem (173174423) PubChem (175736172) PubChem (175683861) PubChem (129428148) PubChem (134814451) PubChem (135391144) PubChem (137700388) PubChem (140604781) PubChem (160897442) PubChem (162935622) PubChem (162935624) PubChem (162935626) PubChem (164186531) PubChem (168311793) PubChem (168313290) PubChem (168314662) PubChem (171378396) PubChem (173032036) PubChem (175764533) | |||
| 5 | Q, R, V (A, B) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 3 | Chemie (LMT) | |||
| 6 | DA, S, Y (E, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 7 | CA, EA, W (D, E, B) | N-OCTANE | non-polymer | 114.2 | 3 | Chemie (OCT) PubChem (356) | |||
| 8 | X (B) | UNDECANE | non-polymer | 156.3 | 1 | Chemie (UND) PubChem (14257) | |||
| 9 | Z (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) |
Sequence modifications
A, B, C, D, E: 1 - 302 (UniProt: O17793)
A, B, C, D, E: 312 - 338 (UniProt: O17793)
| PDB | External Database | Details |
|---|---|---|
| His 340 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
| His 347 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 303 | - | linker |
| Gly 304 | - | linker |
| Thr 305 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 430882.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 7105.4 | |
| All* | Total formula weight | 437988.0 |
