3RHW

C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E	Avermectin-sensitive glutamate-gated chloride channel GluCl alpha	polymer	347	39636.6	5	UniProt (O17793) In PDB	Caenorhabditis elegans (nematode)
2	F, G, H, I, J	Mouse monoclonal Fab fragment, heavy chain	polymer	221	23921.7	5		Mus musculus (mouse)
3	K, L, M, N, O	Mouse monoclonal Fab fragment, light chain	polymer	210	22618.2	5		Mus musculus (mouse)
4	D, A, B	(2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside	non-polymer		875.1	5	Chemie (IVM)
5	A, B	DODECYL-BETA-D-MALTOSIDE	non-polymer		510.6	3	Chemie (LMT)
6	E, B, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
7	D, E, B	N-OCTANE	non-polymer		114.2	3	Chemie (OCT)
8	B	UNDECANE	non-polymer		156.3	1	Chemie (UND)
9	C	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)

Sequence modifications

A, B, C, D, E: 1 - 302 (UniProt: O17793)

PDB	External Database	Details
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag
His 347	-	expression tag

A, B, C, D, E: 312 - 338 (UniProt: O17793)

PDB	External Database	Details
Ala 303	-	linker
Gly 304	-	linker
Thr 305	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	430882.6
Non-Polymers*	Number of molecules	16
	Total formula weight	7105.4
All*	Total formula weight	437988.0

*Water molecules are not included.