3RG9

Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bifunctional dihydrofolate reductase-thymidylate synthase	polymer	240	26220.4	2	Pfam (PF00186) UniProt (by SIFTS) (Q27783)	Trypanosoma brucei rhodesiense	DHFR-TS, Dihydrofolate reductase
2	C, E (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
3	D, F (A, B)	6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE	non-polymer		394.7	2	Chemie (WRA)
4	G, H (A, B)	water	water		18.0	512	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52440.8
Non-Polymers*	Number of molecules	4
	Total formula weight	2280.2
All*	Total formula weight	54721.0

*Water molecules are not included.