3R6G

Crystal structure of active caspase-2 bound with Ac-VDVAD-CHO

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Caspase-2 subunit p18	polymer	160	18093.5	2	UniProt (P42575) Pfam (PF00656)	Homo sapiens (human)
2	B, D (B, D)	Caspase-2 subunit p12	polymer	112	12921.0	2	UniProt (P42575) Pfam (PF00656)	Homo sapiens (human)
3	E, F (F, E)	Peptide Inhibitor (ACE)VDVAD-CHO	polymer	6	527.6	2	BIRD (PRD_001048)
4	G, H, I, J, K... (A, B, C, D, F...)	water	water		18.0	379	Chemie (HOH)

Sequence modifications

A, C: 175 - 333 (UniProt: P42575)

PDB	External Database	Details
Met 174	-	expression tag

B, D: 349 - 452 (UniProt: P42575)

PDB	External Database	Details
Leu 453	-	expression tag
Glu 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	63084.2
All*	Total formula weight	63084.2

*Water molecules are not included.