3R5K

A designed redox-controlled caspase-7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Caspase-7	polymer	312	35456.0	2	UniProt (P55210) Pfam (PF00656) In PDB	Homo sapiens (human)	CASP-7, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3, ICE-LAP3, Caspase-7 subunit p20, Caspase-7 subunit p11
2	A, B	FORMIC ACID	non-polymer		46.0	6	Chemie (FMT)
3		water	water		18.0	104	Chemie (HOH)

Sequence modifications

A, B: 1 - 303 (UniProt: P55210)

PDB	External Database	Details
Met 196	-	expression tag
Cys 210	Arg 210	engineered mutation
Ser 246	Cys 246	engineered mutation
Leu 304	-	expression tag
Glu 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70912.1
Non-Polymers*	Number of molecules	6
	Total formula weight	276.1
All*	Total formula weight	71188.2

*Water molecules are not included.